Selected Publications

Jui-Yen Huang and Hui-Chen Lu (2016) “NGF signaling promotes dendritic outgrowth and morphological complexity in cortical glutamatergic neurons via the TrkA receptor”, submitted to Neuron.

Carlos J Ballester Rosado, Hao Sun, Jui-Yen Huang, and Hui-Chen Lu (2016) “mGluR5 exerts cell-autonomous influences on the functional and anatomical development of layer IV cortical neurons in the mouse primary somatosensory cortex”, in press for Journal of Neuroscience.

Chiaki Itami, Jui-Yen-Huang, Miwako Yamasaki, Masahiko Watanabe, Hui-Chen Lu, and Fumitaka Kimura (2016) “Developmental switch in spike timing-dependent plasticity and cannabinoid-dependent reorganization of the thalamocortical projection in the barrel cortex”,  Journal of Neuroscience 36:7039-7054.

Yousuf O. Ali, Hunter M. Allen, Lei Yu, David Li-Kroger, Dena Bakhshizadehmahmoudi, Asante Hatcher, Christin, McCabe, Jishu Xu, Nicole Bjorklund, Giulio Taglialatela, David A. Bennett, Philip L. De Jager, Joshua M. Shulman, Hugo Bellen, Hui-Chen Lu (2016) “NMNAT2:HSP90 complex mediates proteostasis in proteinopathies”, PLoS Biol. 14(6):e1002472. PMID:27254664.

Richard A. Slivicki, Yousuf O. Ali, Hui-Chen Lu, Andrea G. Hohmann (2016) “Impact of genetic reduction of NMNAT2 on chemotherapy-induced losses in cell viability in vitro and peripheral neuropathy in vivo”, PloS One, 11(1):e0147620. PMID: 26808812.

Hui-Chen Lu and Ken Mackie (2016) “An introduction to the endogenous cannabinoid system”, Biol. Psychiatry, 79:516-25. PMID: 26698193.

Adelina Meadows, Jong Han Lee, Chia-Shan Wu, Qiong Wei, Geetali Pradhan, Michael Yafi, Hui-Chen Lu, and Yuxiang Sun (2016) “Deletion of G-protein coupled receptor 55 promotes obesity by reducing physical activity", in press for International Journal of Obesity. 40:417-24. PMID: 26447738.

Sarah M. Ciupek, Jingheng Cheng, Yousuf O. Ali, Hui-Chen Lu, Daoyun Ji (2015) “Progressive functional impairments of hippocampal neurons in a tauopathy mouse model”,  Journal of Neuroscience 35:8118-31. PMID:   26019329.

Kihoon Han, Hongmei Chen, Vincenzo Alessandro Gennarino, Hui-Chen Lu, Huda Y. Zoghbi (2014) “Fragile X-like behaviors and abnormal cortical dendritic spines in cytoplasmic FMR1 interacting protein 2 mutant mice”, Human Mol. Genetics 24:1813-23. PMCID: PMC4355018.

Hong Lian, Li Yang, Allysa Cole, Lu Sun, Angie C.-A. Chiang, Stephanie W. Fowler, David J. Shim, Jennifer Rodriguez-Rivera, Giulio Taglialatela, Joanna L. Jankowsky, Hui-Chen Lu, Hui Zheng (2014) “NFκB-activated astroglial release of complement C3 compromises neuronal morphology and function associated with Alzheimer’s Disease”, Neuron 85:101-15. PMID: 25533482; PubMed Central PMCID: PMC4289109.

Juan Diego Pita-Almenar, Dinghui Yu, Hui-Chen Lu, Michael Beierlein (2014) “Mechanisms Underlying Desynchronization of Cholinergic-Evoked Thalamic Network Activity”,  Journal of Neuroscience 34(43):14463-14474. PMID: 25339757; PubMed Central PMCID: PMC4205562.

Baiping Wang, Zilai Wang, Lu Sun, Li Yang, Hongmei li, Allysa Cole, Jennifer Rodriguez-Rivera, Hui-Chen Lu, Hui Zheng (2014) “The Amyloid Precursor Protein Controls Adult Hippocampal Neurogenesis through GABAergic Interneurons”,  Journal of Neuroscience 34:13314-25. PMID: 25274811; PubMed Central PMCID: PMC4180470.

Tabassum Majid, Yousuf O. Ali, Deepa V. Venkitararamani, Ming-Kuei Jang, Hui-Chen Lu, Robia G Pautler (2014) “In vivo axonal transport deficits in a mouse model of fronto-temporal dementia”, Neuroimage: Clinical 4:711-7. PMID: 24936422; PubMed Central PMCID: PMC4053640

Chia-Shan Wu, Daniel Morgan, Chris P. Jew, Chris Haskins, Mary-Jeanette Andrews, Corinne M. Spencer, Traci Czyzyk, Heather Bradshaw, Ken Mackie, Hui-Chen Lu (2014) “Long-term consequences of perinatal fatty acid amino hydrolase inhibition”, British J. Pharmacology, 171:1420-34. PMID: 24730060

Kihoon Han,J. Lloyd Holder Jr, Christian P. Schaaf, Hui Lu,  Hongmei Chen, Hyojin Kang, Jianrong Tang, Zhenyu Wu, Shuang Hao, Sau Wai Cheung,      Peng Yu, Hao Sun, Amy M. Breman, Ankita Patel, Hui-Chen Lu, Huda Y. Zoghbi (2013) “SHANK3 duplication causes a hyperkinetic neuropsychiatric disorder with unique pharmacogenetic properties”, Nature 503:72–77.

Chris P. Jew, Chia-Shan Wu, Hao Sun, Jie Zhu, Jui-Yen Huang, Dinghui Yu, Nicholas J. Justice, Hui-Chen Lu (2013) “mGluR5 ablation in cortical glutamatergic neurons increases novelty-induced locomotion”, PLoS ONE, 8:e70415.

Yousuf O. Ali, David Li-Kroeger, Hugo Bellen, R. Grace Zhai, Hui-Chen Lu (2013) NMNATs, evolutionary conserved neuronal maintenance factors, Trends in Neuroscience, 36:632-640.

Chia-Shan Wu, Hongmei Chen, Hao Sun, Jie Zhu, Chris P. Jew, Jim Wager-Miller, Alex Straiker, Corinne Spencer, Heather Bradshaw, Ken Mackie, Hui-Chen Lu (2013) “GPR55, a G protein coupled receptor for lysophosphatidylinositol, plays a role in motor coordination”, PLoS ONE, 8:e60314.

YanGang Sun, Juan Pita-Almenar, Chia-Shan Wu, John J Renger, Victor N. Uebele, Hui-Chen Lu, Michael Beierlein (2013) “Biphasic cholinergic synaptic transmission controls action potential activity in thalamic reticular nucleus neurons”, Journal of Neuroscience 33: 2048-59.

Javier Díaz, Tania Aguado, Chia-Shan Wu, Javier Palazuelos, Beat Lutz, Hui-Chen Lu, Manuel Guzmán, Ismael Galve-Roperh (2012) “CB1 cannabinoid receptor regulation of Pax-6 and Tbr-2 controls pyramidal neurogenesis and cortical layer specification”, Journal of Neuroscience 32: 16651-65.

Chia-Chien Chen, Hui-Chen Lu, Joshua C. Brumberg (2012) “mGluR5 knockout mice display increased dendritic spine densities”, Neuroscience Letters 524:65-68.

Harry Han, Carolyn A. Allen, Christie M. Buchovecky, Michael J. Yetman, Heather A. Born, Miguel A. Marin, Shaefali P. Rodgers, Bryan Song, Hui-Chen Lu, Monica Justice, Frank J. Probst, and Joanna L. Jankowsky (2012) “Strain background influences neurotoxicity and behavioral abnormalities in mice expressing the tetracycline transactivator”, Journal of Neuroscience 32:10574-10586.

YanGang Sun, Chia-Shan Wu, John J Renger, Victor N. Uebele, Hui-Chen Lu, Michael Beierlein (2012) “GABAergic synaptic transmission triggers action potentials in thalamic reticular nucleus neurons”,  Journal of Neuroscience. 32:7782-90.

Cecilia Ljungberg, Yousuf Ali, Jie Zhu, Chia-Shan Wu, Kazuhiro Oka, R.Grace Zhai, Hui-Chen Lu (2012) “CREB-activity and nmnat2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy”, Human Mol. Genetics, 15:251-67.

Chia-Shan Wu, Carlos J. Ballester Rosado, Hui-Chen Lu (2011) “What can we get from “BARRELs” -the rodent barrel cortex as a model to study the establishment of neural circuits”, European J. Neuroscience, 34:1663-76.

Chia-Shan Wu, Christopher P. Jew, Hui-Chen Lu (2011) “Lasting impacts of prenatal cannabis exposure and the role of endogenous cannabinoids in the developing brain”, Future Neurology, 6:459-480.

YanGang Sun, Chia-Shan Wu, Hui-Chen Lu, Michael Beierlein “Target-dependent control of synaptic inhibition by endocannabinoids in the thalamus” (2011),  Journal of Neuroscience, 31:9222-30.

Joanna S.T. Asprer, Bora Lee, Chia-Shan Wu, Tegy Vadakkan, Mary Dickinson, Hui-Chen Lu, Soo-Kyung Lee (2011) “LMO4 functions as a co-activator of neurogenin 2 in the developing cortex”, Development, 138:2823-32.

Carlos J. Ballester Rosado, Michael J Albright, Chia-Shan Wu, Chun-Chieh Liao, Jie Zhu, Shen-Ju Chou, Dennis D O'Leary, Li-Jen Lee, and Hui-Chen Lu (2010) “mGluR5 in cortical excitatory neurons exerts both cell autonomous and nonautonomous influences on cortical somatosensory circuit formation”,  Journal of Neuroscience, 30:16896-909.

Hsiao-Tuan Chao, Hongmei Chen, Rodney C. Samaco, Mingshan Xue, Maria Chahrour, Jong Yoo, Jeffrey L. Neul, Shiaoching Gong, Hui-Chen Lu, Nathaniel Heintz, Marc Ekker, John L.R. Rubnenstein, Jeffrey L, Noebels, Christian Rosenmund, Huda Y. Zoghbi (2010) “GABAergic dysfunction mediates autism-like stereotypies and numerous features of Rett syndrome”, Nature, 468(7321):263-9.

Chia-Shan Wu, Jie Zhu, Jim Wager-Miller, Shan Wang, Dennis O'Leary, Krisztina Monory, Beat Lutz, Ken Mackie, and Hui-Chen Lu (2010) “Requirement of cannabinoid CB1 receptor in cortical pyramidal neurons for appropriate development of corticothalamic and thalamocortical projections”, European J. Neuroscience, 32:693-706.

Keiko Sakai, Oliver Tiebel, Cecilia Ljungberg, Merry Sullivan, Hey-Jeong Lee, Tomoya Terashima, Rongying Li, Kunihisa Kobayashi, Hui-Chen Lu, Lawrence Chan, Kazuhiro Oka (2009) “A neuronal VLDLR variant lacking the third complement-type repeat exhibits high capacity binding of ApoE containing lipoproteins”, Brain Research, 1276:11-21.

Wei-Chi She, Charles Quairiaux, Michael J. Albright, Yu-Chi Wang, Denisse E. Sanchez, Poh-Shing Chang, Egbert Welker, Hui-Chen Lu (2009) “Roles of mGluR5 in synaptic function and plasticity of the mouse thalamocortical pathway”, European J. Neuroscience, 29: 1379–1396 (EJN featured article).

Yuan Fan, Ping Deng, Yu-Chi Wang, Hui-Chen Lu, Zao C Xu, Paul E Schulz (2008) “Transient cerebral ischemia increases CA1 pyramidal neurons excitability”, Experimental Neurology, 212: 415-421.

Jan Mulder, Tania Aguado, Erik Keimpema, Klaudia Barabás, Carlos J. Ballester Rosado, Laurent Nguyen, Krisztina Monory, Giovanni Marsicano, Vincenzo Di Marzo, Yasmin L. Hurd, Francois Guillemo, Ken Mackie, Beat Lutz, Manuel Guzman, Hui-Chen Lu, Ismael Galve-Roperh, Tibor Harkany (2008) “Endocannabinoid signaling controls pyramidal cell specification and corticothalamic axon patterning”, Proc Natl Acad Sci U S A, 105:8760-8765.

Jane E. Lauckner, Jill B. Jensen, Huei-Ying Chen, Hui-Chen Lu, Bertil Hille, and Ken Mackie (2008) “GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current, Proc Natl Acad Sci U S A, 105: 2699-2704.

Melis Inan, Hui-Chen Lu, Michael Albright, Wei-Chi She and Michael C. Crair (2006) Barrel map development relies on PKARIIβ –mediated cAMP signaling”, Journal of Neuroscience, 26: 4338-4349.

Hui-Chen Lu, Daniel A Butts, Pascal S. Kaeser, Wei-Chi She, Roger Janz and Michael C. Crair (2006) Role of efficient neurotransmitter release in barrel map development”, Journal of Neuroscience, 26: 2692-2703.

Hui-Chen Lu, Wei-Chi She, Daniel T. Plas, Paul E. Neumann, Roger Janz, Michael C. Crair (2003) Adenylyl cyclase I regulates AMPA receptor trafficking during mouse cortical ‘barrel’ map development”, Nature Neuroscience, 6: 939-947.

Hui-Chen Lu, Ernesto Gonazlez, and Michael C. Crair (2001) Barrel cortex critical period plasticity is independent of changes in NMDA receptor subunit composition”, Neuron, 32: 619-634.