In our latest publication, a large-scale discovery assay was used to identify factors that increases NMNAT2 levels in the brain. One of those compounds was caffeine, and it has drawn some attention!
In the most recent publication from the Lu Laboratory in Scientific Reports, various compounds were screened for their effect on NMNAT2 levels -- a protein we previously identified for its protective role in Alzheimer's disease. Graduate student Gillian Bradley and assistant faculty Dr. Yousuf Ali were the primary contributors to the project with Dr. Hui-Chen Lu.
On December, 7th, Dr. Hui-Chen Lu, Dr. Yousuf Ali, and Hunter Allen were featured on Reddit as a part of the /r/science "Ask Me Anything" series, where they answered questions from users around the world regarding their recently published work on NMNAT2 in PLoS Biology.
We've just published a new paper in The Journal of Neuroscience describing the role of mGluR5 in cortical neuron development. Follow the link below to read the full article.
The American Federation for Aging Research chose to highlight a few of our collaborators, Dr. Giulio Taglialatela and Dr. Joshua Shulman, for their contributions to our most recent publication in PLOS Biology.
We have just published a new paper, now in press in PLOS Biology, focusing on NMNAT2's role as a molecular chaperone and neuronal maintenance factor in the context of Alzheimer's disease and other proteinopathies.