Principal Investigator

Hui-Chen Lu, is a Gill Chair of Neuroscience in the Department of Psychological and Brain Sciences at Indiana University. She received her Ph.D. from Baylor College of Medicine, Houston. Her research focuses on the signaling cascades underlying neural circuit connections during brain development, to understand how sensory experiences affect neural circuit wiring, and to identify novel factors required to maintain the health of neural circuits during aging.

Education:

  • B.S., National Taiwan University, 1991
  • Ph.D., Baylor College of Medicine, 1997
  • Postdoctoral Fellow, Baylor College of Medicine, 1997-2003

Current Research:

  • Development of cortical neural circuits, in particular on activity-dependent remodeling and how to correct mis-wiring in neurological disorders.
  • Neuroprotective strategies to reserve cognition and to protect against dementia.

ASSISTANT SCIENTISTS

Jui-Yen Huang, Ph.D. juiyhuan@iu.edu Curriculum Vitae

Current Research:

  • The role of FGF/FGFR signaling in brain circuitry formation and maintenance.
  • The underlying mechanisms that regulate FGF/FGFR expression.

Post-Doctoral Fellows

Salil Sharma, Ph.D. salishar@iu.edu Curriculum Vitae

Salil Sharma is a postdoctoral fellow in the Department of Psychological and Brain Sciences at Indiana University. He received his Ph.D. from University of Miami School of Medicine. He has a long-standing interest in exploring the role of microRNAs and other non-coding regulatory molecules in various diseases. He is currently pursuing the possibility to use circulating microRNAs as biomarkers as well as therapeutic targets for neurodegenerative diseases including Alzheimer’s disease (AD).

Education:

  • M.S., Bangalore University, India 2003
  • Ph.D., University of Miami School of Medicine, 2011
  • Postdoctoral Fellow, University of California Los Angeles, 2012-2015

Current Research:

  • Study the mechanistic role of noncoding RNA molecules, in particular, circulating microRNAs as regulatory molecules that contribute to the onset and progression of AD.
  • Identify circulating miRNAs that are altered in early AD, and could ultimately and reliably be used as biomarkers to monitor pathological changes in AD patients.

Graduate Students

Sen Yang is a dual Ph.D. student in Psychology & Brain Sciences and Neuroscience at Indiana University Bloomington. Her research interest is in neurodegenerative disease, specifically in the synaptic loss associated with Alzheimer's disease, and mechanisms of learning, memory, and consciousness.

 

Research Technicians

Hunter is a research technician from Dallas, TX who began working with Dr. Lu before the lab moved from Baylor College of Medicine in Houston, TX. He currently heads-up the operation of the multi-photon microscope in the lab, both performing active research and training users in the operation of the scope. He is also responsible for managing lab IT functions, training individuals in basic laboratory procedures, and assisting with technical and computing activities such as Matlab, Python, and other programming for data analysis.

Education:

  • B.S. in Neurobiology, University of Texas at Austin, 2012

Current Research:

  • Longitudinal in vivo multi-photon imaging studies of neurodegeneration in the context of Alzheimer's disease with a focus on the involvement of the NMNAT2 protein.
  • In vivo multi-photon studies of microglial changes under various neurobiological conditions
 
Bruce Henry bhenry@iupui.edu

Bruce Henry

bhenry@iupui.edu

Bruce joined the Lu laboratory after working for many years as in the microscopy core at Indiana University-Purdue University Indianapolis. He now assists with both surgical procedures and in vivo multi-photon microscopy. His hobbies are canoeing, backpacking, camping, fishing, geology, and wood working.

Education:

  • B.S., University of Indianapolis, 1973
 
Bruna Krebs Kutche baumgarb@indiana.edu

Bruna Krebs Kutche

baumgarb@indiana.edu

Bruna is a Research Technician from Rio de Janeiro, Brazil. She studied at UNIRIO - Federal University of the State of Rio de Janeiro, and majored in Biology. She has previously done research in Bioinformatics. At the Lu Lab, she is responsible for the multi-photon microscope operation, performing in vitro, in vivo, and eventually awake behaving imaging studies. She also performs data analysis and manages the lab IT functions.

Education:

  • B.S. in Biology, UNIRIO - Federal University of the State of Rio de Janeiro, Brazil, 2016
 
Julie Jacobs jujacob@iu.edu

Julie Jacobs

jujacob@iu.edu

Julie joined the Lu Laboratory after retiring from Eli Lilly and Co. in Indianapolis, working mainly in in vivo labs exploring GI, obesity, and diabetes discovery research. She has become the lab manager and is focusing on using rAAV to manipulate gene expressions in brains and conducting behavioral testing. Julie enjoys her family, camping, antiques, and doing conformation and performance sports with her dogs.

Education:

  • AAS in Veterinary Technology, Purdue University, 1977
 
Zhen Xian Niou niouz@iu.edu

Zhen Xian Niou

niouz@iu.edu

Zhen Xian is a Research Technician from Taiwan. His research interest is in neural circuitry and development. He assists with cryosectioning and staining in the lab. He is also learning patch clamp and will try to use this technique for further research. 

Education:

  • B.S., National Taiwan Ocean University, 2012

Undergraduate & High-School Students

Tiffany Xie tifxie@indiana.edu

Tiffany Xie is an undergraduate studying Biology and English. She joined the Lu Lab in 2017 with a focus on Molecular Biology. She writes for the Indiana University Journal of Undergraduate Research blog and is a violist in the Bloomington Symphony Orchestra. Her current project involves examining neurodevelopmental changes in mGluR5 conditional knockout mice.

 
Jessica Felker jrfelker@indiana.edu

Jessica Felker

jrfelker@indiana.edu

Jessica is a Freshman at Indiana University, and plan to pursue a degree in Neuroscience. She is from Indianapolis, where she graduated from Nexus Academy. She has conducted research as a high school student at Riley Hospital in Ophthalmology, as well as at Eli Lilly in Diabetes. Her career goal is to become a pediatric surgeon as well as continue in research.
 

 
Michael Hess mdhess@bsu.edu

Michael Hess

mdhess@bsu.edu

Michael Hess is a senior attending Brown County High School. He plans to graduate at the top of his class in June of 2017. Afterwards, his plans are to attend a high-ranking university that offers a degree in neuroscience. He ultimately plans to be a neurosurgeon focusing mainly on spine surgery.

 

Jie-En Wu is an undergraduate majoring in Neuroscience. She has been in the Lu Lab since 2016, working in mice management. Currently, she is also assisting the research of Dr. Jonathon Crystal. Additionally, she is a member of Alpha Chi Sigma, as well as the Longboarding Club.

 

Adam is currently pursuing majors in both Biology and Spanish. He is a Senior and a Pre-Med student as well. Currently he is applying to the Indiana University School of Medicine and hopes to attend starting in the Fall of 2018. In the lab he assists Dr. Salil Sharma with his work with mir142.


Former Lab Members

Gillian Bradley gillian.m.bradley@gmail.com Currently at Penn FTD Center

Gillian Bradley
gillian.m.bradley@gmail.com

Currently at Penn FTD Center

Dena B. Mahmoudi denabakh@indiana.edu  

Dena B. Mahmoudi
denabakh@indiana.edu

 

Jason Graf jasongraf6@yahoo.com Currently at Baylor College of Medicine

Jason Graf
jasongraf6@yahoo.com

Currently at Baylor College of Medicine

Marisha Miskus mmiskus@imail.iu.edu  

Marisha Miskus
mmiskus@imail.iu.edu

 

Carlos Ballester cb143163@bcm.edu Currently at Baylor College of Medicine

Carlos Ballester
cb143163@bcm.edu

Currently at Baylor College of Medicine

Jie Zhu zhujie.usa@hotmail.com Currently at Baylor Genetics Lab

Jie Zhu
zhujie.usa@hotmail.com

Currently at Baylor Genetics Lab

Chia-Shan Wu cjwu@tamu.edu Currently at Texas A&M University

Chia-Shan Wu
cjwu@tamu.edu

Currently at Texas A&M University


Honorary Lab Members

Misty Theodore

Misty Theodore

Jana England

Jana England

Misty and Jana are the core administrators for the Gill Center and, with their invaluable assistance, have made the research of the all of the Gill Center laboratories possible.

 
Richard Moore

Richard Moore

Jesse Goode

Jesse Goode

Rick and Jesse head-up the workshop for the psychology department. They have helped in numerous ways, including lab modifications to facilitate our work and manufacture of custom tools and prototypes that aid in our ongoing research projects.